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Browse the official clinical code repository for active CPT procedure classifications. Up to 50 codes are displayed per page.
| Code | Category / Specialty | Description |
|---|---|---|
| 81443 |
Procedures
General
|
Genetic testing for severe inherited conditions (eg, cystic fibrosis, Ashkenazi Jewish-associated disorders [eg, Bloom syndrome, Canavan disease, Fanconi anemia type C, mucolipidosis type VI, Gaucher disease, Tay-Sachs disease], beta hemoglobinopathies, phenylketonuria, galactosemia), genomic sequence analysis panel, must include sequencing of at least 15 genes (eg, ACADM, ARSA, ASPA, ATP7B, BCKDHA, BCKDHB, BLM, CFTR, DHCR7, FANCC, G6PC, GAA, GALT, GBA, GBE1, HBB, HEXA, IKBKAP, MCOLN1, PAH)
|
| 81445 |
Procedures
General
|
Targeted genomic sequence analysis panel, solid organ neoplasm, DNA analysis, and RNA analysis when performed, 5-50 genes (eg, ALK, BRAF, CDKN2A, EGFR, ERBB2, KIT, KRAS, NRAS, MET, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, if performed
|
| 81448 |
Procedures
General
|
Hereditary peripheral neuropathies (eg, Charcot-Marie-Tooth, spastic paraplegia), genomic sequence analysis panel, must include sequencing of at least 5 peripheral neuropathy-related genes (eg, BSCL2, GJB1, MFN2, MPZ, REEP1, SPAST, SPG11, SPTLC1)
|
| 81449 |
Procedures
General
|
Targeted genomic sequence analysis panel, solid organ neoplasm, 5-50 genes (eg, ALK, BRAF, CDKN2A, EGFR, ERBB2, KIT, KRAS, MET, NRAS, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, if performed; RNA analysis
|
| 81450 |
Procedures
General
|
Targeted genomic sequence analysis panel, hematolymphoid neoplasm or disorder, DNA analysis, and RNA analysis when performed, 5-50 genes (eg, BRAF, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KRAS, KIT, MLL, NRAS, NPM1, NOTCH1), interrogation for sequence variants, and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed
|
| 81451 |
Procedures
General
|
Targeted genomic sequence analysis panel, hematolymphoid neoplasm or disorder, 5-50 genes (eg, BRAF, CEBPA, DNMT3A, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NOTCH1, NPM1, NRAS), interrogation for sequence variants, and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; RNA analysis
|
| 81455 |
Procedures
General
|
Targeted genomic sequence analysis panel, solid organ or hematolymphoid neoplasm, DNA analysis, and RNA analysis when performed, 51 or greater genes (eg, ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MLL, NPM1, NRAS, MET, NOTCH1, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, if performed
|
| 81456 |
Procedures
General
|
Targeted genomic sequence analysis panel, solid organ or hematolymphoid neoplasm or disorder, 51 or greater genes (eg, ALK, BRAF, CDKN2A, CEBPA, DNMT3A, EGFR, ERBB2, EZH2, FLT3, IDH1, IDH2, JAK2, KIT, KRAS, MET, MLL, NOTCH1, NPM1, NRAS, PDGFRA, PDGFRB, PGR, PIK3CA, PTEN, RET), interrogation for sequence variants and copy number variants or rearrangements, or isoform expression or mRNA expression levels, if performed; RNA analysis
|
| 81457 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis, microsatellite instability
|
| 81458 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis, copy number variants and microsatellite instability
|
| 81459 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants, microsatellite instability, tumor mutation burden, and rearrangements
|
| 81460 |
Procedures
General
|
Whole mitochondrial genome (eg, Leigh syndrome, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes [MELAS], myoclonic epilepsy with ragged-red fibers [MERFF], neuropathy, ataxia, and retinitis pigmentosa [NARP], Leber hereditary optic neuropathy [LHON]), genomic sequence, must include sequence analysis of entire mitochondrial genome with heteroplasmy detection
|
| 81462 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants and rearrangements
|
| 81463 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis, copy number variants, and microsatellite instability
|
| 81464 |
Procedures
General
|
Solid organ neoplasm, genomic sequence analysis panel, cell-free nucleic acid (eg, plasma), interrogation for sequence variants; DNA analysis or combined DNA and RNA analysis, copy number variants, microsatellite instability, tumor mutation burden, and rearrangements
|
| 81465 |
Procedures
General
|
Whole mitochondrial genome large deletion analysis panel (eg, Kearns-Sayre syndrome, chronic progressive external ophthalmoplegia), including heteroplasmy detection, if performed
|
| 81470 |
Procedures
General
|
X-linked intellectual disability (XLID) (eg, syndromic and non-syndromic XLID); genomic sequence analysis panel, must include sequencing of at least 60 genes, including ARX, ATRX, CDKL5, FGD1, FMR1, HUWE1, IL1RAPL, KDM5C, L1CAM, MECP2, MED12, MID1, OCRL, RPS6KA3, and SLC16A2
|
| 81471 |
Procedures
General
|
X-linked intellectual disability (XLID) (eg, syndromic and non-syndromic XLID); duplication/deletion gene analysis, must include analysis of at least 60 genes, including ARX, ATRX, CDKL5, FGD1, FMR1, HUWE1, IL1RAPL, KDM5C, L1CAM, MECP2, MED12, MID1, OCRL, RPS6KA3, and SLC16A2
|
| 81479 |
Procedures
General
|
Unlisted molecular pathology procedure
|
| 81490 |
Procedures
General
|
Autoimmune (rheumatoid arthritis), analysis of 12 biomarkers using immunoassays, utilizing serum, prognostic algorithm reported as a disease activity score
|
| 81493 |
Procedures
General
|
Coronary artery disease, mRNA, gene expression profiling by real-time RT-PCR of 23 genes, utilizing whole peripheral blood, algorithm reported as a risk score
|
| 81500 |
Procedures
General
|
Oncology (ovarian), biochemical assays of two proteins (CA-125 and HE4), utilizing serum, with menopausal status, algorithm reported as a risk score
|
| 81503 |
Procedures
General
|
Oncology (ovarian), biochemical assays of five proteins (CA-125, apolipoprotein A1, beta-2 microglobulin, transferrin, and pre-albumin), utilizing serum, algorithm reported as a risk score
|
| 81504 |
Procedures
General
|
Oncology (tissue of origin), microarray gene expression profiling of > 2000 genes, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as tissue similarity scores
|
| 81506 |
Procedures
General
|
Endocrinology (type 2 diabetes), biochemical assays of seven analytes (glucose, HbA1c, insulin, hs-CRP, adiponectin, ferritin, interleukin 2-receptor alpha), utilizing serum or plasma, algorithm reporting a risk score
|
| 81507 |
Procedures
General
|
Fetal aneuploidy (trisomy 21, 18, and 13) DNA sequence analysis of selected regions using maternal plasma, algorithm reported as a risk score for each trisomy
|
| 81508 |
Procedures
General
|
Fetal congenital abnormalities, biochemical assays of two proteins (PAPP-A, hCG [any form]), utilizing maternal serum, algorithm reported as a risk score
|
| 81509 |
Procedures
General
|
Fetal congenital abnormalities, biochemical assays of three proteins (PAPP-A, hCG [any form], DIA), utilizing maternal serum, algorithm reported as a risk score
|
| 81510 |
Procedures
General
|
Fetal congenital abnormalities, biochemical assays of three analytes (AFP, uE3, hCG [any form]), utilizing maternal serum, algorithm reported as a risk score
|
| 81511 |
Procedures
General
|
Fetal congenital abnormalities, biochemical assays of four analytes (AFP, uE3, hCG [any form], DIA) utilizing maternal serum, algorithm reported as a risk score (may include additional results from previous biochemical testing)
|
| 81512 |
Procedures
General
|
Fetal congenital abnormalities, biochemical assays of five analytes (AFP, uE3, total hCG, hyperglycosylated hCG, DIA) utilizing maternal serum, algorithm reported as a risk score
|
| 81515 |
Procedures
General
|
Infectious disease, bacterial vaginosis and vaginitis, real-time PCR amplification of DNA markers for Atopobium vaginae, Atopobium species, Megasphaera type 1, and Bacterial Vaginosis Associated Bacteria-2 (BVAB-2), utilizing vaginal-fluid specimens, algorithm reported as positive or negative for high likelihood of bacterial vaginosis, includes separate detection of Trichomonas vaginalis and Candida species (C. albicans, C. tropicalis, C. parapsilosis, C. dubliniensis), Candida glabrata/Candida krusei, when reported
|
| 81517 |
Procedures
General
|
Liver disease, analysis of 3 biomarkers (hyaluronic acid [HA], procollagen III amino terminal peptide [PIIINP], tissue inhibitor of metalloproteinase 1 [TIMP-1]), using immunoassays, utilizing serum, prognostic algorithm reported as a risk score and risk of liver fibrosis and liver-related clinical events within 5 years
|
| 81518 |
Procedures
General
|
Oncology (breast), mRNA, gene expression profiling by real-time RT-PCR of 11 genes (7 content and 4 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithms reported as percentage risk for metastatic recurrence and likelihood of benefit from extended endocrine therapy
|
| 81519 |
Procedures
General
|
Oncology (breast), mRNA, gene expression profiling by real-time RT-PCR of 21 genes, utilizing formalin-fixed paraffin embedded tissue, algorithm reported as recurrence score
|
| 81520 |
Procedures
General
|
Oncology (breast), mRNA gene expression profiling by hybrid capture of 58 genes (50 content and 8 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a recurrence risk score
|
| 81521 |
Procedures
General
|
Oncology (breast), mRNA, microarray gene expression profiling of 70 content genes and 465 housekeeping genes, utilizing fresh frozen or formalin-fixed paraffin-embedded tissue, algorithm reported as index related to risk of distant metastasis
|
| 81522 |
Procedures
General
|
Oncology (breast), mRNA, gene expression profiling by RT-PCR of 12 genes (8 content and 4 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as recurrence risk score
|
| 81523 |
Procedures
General
|
Oncology (breast), mRNA, next-generation sequencing gene expression profiling of 70 content genes and 31 housekeeping genes, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as index related to risk to distant metastasis
|
| 81524 |
Procedures
General
|
Oncology (central nervous system tumor), DNA methylation analysis of at least 10,000 methylation sites, utilizing DNA extracted from formalin-fixed tumor tissue, algorithm(s) reported as probability of matching a reference tumor family and class, and MGMT (O-6-methylguanine-DNA methyltransferase) promoter methylation status, if performed
|
| 81525 |
Procedures
General
|
Oncology (colon), mRNA, gene expression profiling by real-time RT-PCR of 12 genes (7 content and 5 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a recurrence score
|
| 81528 |
Procedures
General
|
Oncology (colorectal) screening, quantitative real-time target and signal amplification of 10 DNA markers (KRAS mutations, promoter methylation of NDRG4 and BMP3) and fecal hemoglobin, utilizing stool, algorithm reported as a positive or negative result
|
| 81535 |
Procedures
General
|
Oncology (gynecologic), live tumor cell culture and chemotherapeutic response by DAPI stain and morphology, predictive algorithm reported as a drug response score; first single drug or drug combination
|
| 81536 |
Procedures
General
|
Oncology (gynecologic), live tumor cell culture and chemotherapeutic response by DAPI stain and morphology, predictive algorithm reported as a drug response score; each additional single drug or drug combination (List separately in addition to code for primary procedure)
|
| 81538 |
Procedures
General
|
Oncology (lung), mass spectrometric 8-protein signature, including amyloid A, utilizing serum, prognostic and predictive algorithm reported as good versus poor overall survival
|
| 81539 |
Procedures
General
|
Oncology (high-grade prostate cancer), biochemical assay of four proteins (Total PSA, Free PSA, Intact PSA, and human kallikrein-2 [hK2]), utilizing plasma or serum, prognostic algorithm reported as a probability score
|
| 81540 |
Procedures
General
|
Oncology (tumor of unknown origin), mRNA, gene expression profiling by real-time RT-PCR of 92 genes (87 content and 5 housekeeping) to classify tumor into main cancer type and subtype, utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a probability of a predicted main cancer type and subtype
|
| 81541 |
Procedures
General
|
Oncology (prostate), mRNA gene expression profiling by real-time RT-PCR of 46 genes (31 content and 15 housekeeping), utilizing formalin-fixed paraffin-embedded tissue, algorithm reported as a disease-specific mortality risk score
|
| 81542 |
Procedures
General
|
Oncology (prostate), mRNA, microarray gene expression profiling of 22 content genes, utilizing formalin-fixed paraffin embedded tissue, algorithm reported as metastasis risk score
|
| 81545 |
Procedures
General
|
Oncology (thyroid), gene expression analysis of 142 genes, utilizing fine needle aspirate, algorithm reported as a categorical result (eg, benign or suspicious)
|
The Current Procedural Terminology (CPT®) code set, maintained and copyrighted by the American Medical Association (AMA), is the universal language of medicine in the United States outpatient setting. It is utilized to report medical, surgical, and diagnostic procedures and services to entities such as physicians, health insurance companies, and accreditation organizations. For the Certified Professional Coder (CPC), mastering the CPT manual is the cornerstone of professional fee (ProFee) and ambulatory surgery center (ASC) coding.
Unlike ICD-10-CM which describes the "why" (the diagnosis), CPT describes the "what" (the service or procedure performed). Translating a complex operative report or an Evaluation and Management (E/M) encounter into a 5-digit CPT code requires a profound understanding of medical terminology, anatomy, and the labyrinth of AMA guidelines. A single coding error can result in massive revenue leakage, compliance violations, or severe audit penalties.
Never code directly from the alphabetic index. The true power of the CPC lies in reading the parenthetical notes situated directly beneath the CPT codes in the tabular section. These notes dictate bundling rules, direct the coder to the correct alternative codes, and provide strict instructions on when a modifier is necessary. Ignoring a parenthetical note is a guaranteed path to a claim denial.
The CPT code set is divided into three distinct categories, each serving a unique purpose in the healthcare ecosystem.
These are the core, 5-digit numeric codes that make up the vast majority of the CPT manual. They represent procedures and services that are widely performed by many healthcare professionals in clinical practice and are approved by the FDA. Category I is divided into six main sections:
These are supplemental tracking codes used for performance measurement and quality tracking. They are alphanumeric (e.g., 3008F - Body Mass Index documented). While Category II codes are generally optional and do not carry a relative value unit (RVU) for direct reimbursement, they are highly critical in value-based purchasing agreements, MIPS (Merit-based Incentive Payment System), and MACRA reporting to secure quality bonuses.
These are temporary alphanumeric codes (ending in "T") utilized for emerging technologies, services, and procedures (e.g., 0101T - Extracorporeal shock wave involving musculoskeletal system). They allow researchers and the AMA to track the utilization of new technologies before they are granted Category I status. If a Category III code exists for a specific procedure, it must be utilized instead of an "unlisted" Category I code.
Historically, E/M coding was the most heavily audited and contentious area of medical coding, governed by the archaic 1995 and 1997 CMS Documentation Guidelines. These old guidelines required physicians to "bullet count" physical exam elements and history of present illness (HPI) components, leading to massive documentation bloat ("note bloat") in Electronic Health Records.
The AMA and CMS radically overhauled E/M coding (effective 2021 for outpatient/office, and 2023 for inpatient/facility). Today, the selection of an E/M level is based strictly on one of two criteria:
Surgical coding is governed by the concept of the Global Surgical Package. When a payer reimburses a surgical CPT code, the payment covers not just the intraoperative procedure, but also the local/topical anesthesia, normal uncomplicated follow-up care, and typical preoperative encounters.
One of the primary directives of a CPC is to prevent Unbundling. Unbundling occurs when a coder reports multiple CPT codes for components that are inherently part of a single, major procedure. To prevent this, coders rely on the National Correct Coding Initiative (NCCI) Edits. These edits dictate which codes cannot be billed together. For example, you cannot bill an exploratory laparotomy alongside an open appendectomy, as the surgical approach is bundled into the definitive procedure.
Modifiers are two-digit codes appended to a CPT code to indicate that a service or procedure has been altered by some specific circumstance but not changed in its definition. Applying the correct modifier is the ultimate test of a coder's compliance knowledge. Incorrect modifier usage is the leading cause of Office of Inspector General (OIG) audits.
CPT codes are intrinsically tied to physician compensation via the Medicare Physician Fee Schedule (MPFS). Every Category I CPT code is assigned a Relative Value Unit (RVU), which quantifies the resources required to perform the service. The total RVU is calculated by adding three components:
The Total RVU is then multiplied by a geographic practice cost index (GPCI) and the annual Medicare Conversion Factor to calculate the exact dollar amount of reimbursement.
The Certified Professional Coder is the final line of defense in the revenue cycle. A physician may perform an incredible, life-saving surgery, but if the CPC fails to correctly sequence the CPT codes, apply the correct NCCI bypass modifiers, or link the procedures to the highest-specificity ICD-10-CM diagnosis codes to prove Medical Necessity, the claim will be denied.
Beyond abstracting codes from documentation, modern CPCs act as clinical educators. They regularly audit provider documentation to ensure compliance with AMA guidelines, train physicians on the nuances of the 2021/2023 E/M updates, and query providers when an operative report lacks the critical details required to assign a complex surgical code.
The CPT code set is a dynamic, continuously evolving language that adapts to the cutting edge of medical science. New technologies, novel surgical techniques, and telemedicine expansions require the AMA to update the manual annually every January 1st.
For the professional medical coder, fluency in CPT is the key to unlocking the financial viability of a healthcare organization. It demands rigorous analytical skills, an unwavering commitment to ethical compliance, and a deep respect for the clinical realities of patient care. Whether you are coding a simple office visit or a multi-stage cardiothoracic surgery, your mastery of CPT ensures that the physician's work is accurately recognized, fully reimbursed, and protected from retrospective audits.
Welcome to the most comprehensive and lightning-fast CPT code lookup tool available online. Whether you are a dedicated health information management (HIM) professional, a certified medical coder, a specialized biller, or a clinical data analyst, our advanced search engine allows you to instantly search CPT codes and find highly accurate code descriptions in mere milliseconds. Navigating the complex world of healthcare terminology requires precision, and our platform is built to deliver exactly that.
Looking up medical codes can often be a frustrating and time-consuming experience, especially when relying on slow, clunky platforms or physical manuals that quickly become outdated. Our dedicated CPT search directory elegantly bridges that gap. By utilizing our highly optimized, state-of-the-art database, you can effortlessly find CPT code descriptions by simply typing a keyword, a specific diagnosis or procedure, an anatomical site, or the exact alphanumeric code itself. The results are rendered in real-time as you type, allowing you to completely bypass cumbersome PDF manuals and heavy physical coding books, streamlining your daily workflow.
To perform an accurate CPT lookup, navigate to the intuitive search bar located at the top of this page. If you have a specific clinical term or abstract concept in mind, simply type the term into the search field. Our intelligent, NLP-driven algorithm will instantly scan the entire official database to populate a comprehensive list of matching CPT codes and descriptions. Conversely, if you already possess the specific code and simply need to verify its validity or read the full tabular guidelines, you can type the identifier directly into the bar to instantly verify its official long-form description.
Our platform is meticulously engineered specifically for medical coders, billers, and clinical analysts who demand both speed and unwavering accuracy. When you search for CPT codes on our website, you are guaranteed to receive the exact, official nomenclature published by the governing bodies. We provide the full tabular descriptions, ensuring that you understand the precise clinical nuances, including essential modifiers, bundling edits, and specific indicators required for clean claim submission and flawless clinical documentation.
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We highly recommend that you bookmark this page as your daily, primary resource for all your CPT code search needs. We are deeply committed to maintaining this robust, frequently updated database as a permanent, free public utility for the global healthcare data community. Start typing your query into the search bar above to experience the absolute fastest, most reliable medical code lookup available on the internet today. Say goodbye to endless scrolling, frustrating page loads, and outdated indexes. Let our powerful, instantaneous search engine do the heavy lifting for your clinical documentation and coding operations. Whether you are aggressively searching by an exact code, a partial clinical description, or a broad medical category, our advanced tool delivers the exact CPT code information you need to ensure total compliance and financial accuracy.