Official Coding Guidelines

CPT Dictionary

Search the complete CPT database. Access official guidelines, notes, modifiers, and documentation requirements instantly.

CPT Code Reference Directory

Browse the official clinical code repository for active CPT procedure classifications. Up to 50 codes are displayed per page.

Code Category / Specialty Description
0327U
Procedures
General
Fetal aneuploidy (trisomy 13, 18, and 21), DNA sequence analysis of selected regions using maternal plasma, algorithm reported as a risk score for each trisomy, includes sex reporting, if performed
0328T
Procedures
General
Programming device evaluation (in person) with iterative adjustment of the implantable device to test the function of the device and select optimal permanent programmed values with analysis; implantable subcutaneous lead defibrillator system
0328U
Procedures
General
Drug assay, definitive, 120 or more drugs and metabolites, urine, quantitative liquid chromatography with tandem mass spectrometry (LC-MS/MS), includes specimen validity and algorithmic analysis describing drug or metabolite and presence or absence of risks for a significant patient-adverse event, per date of service
0329T
Procedures
General
Monitoring of intraocular pressure for 24 hours or longer, unilateral or bilateral, with interpretation and report
0329U
Procedures
General
Oncology (neoplasia), exome and transcriptome sequence analysis for sequence variants, gene copy number amplifications and deletions, gene rearrangements, microsatellite instability and tumor mutational burden utilizing DNA and RNA from tumor with DNA from normal blood or saliva for subtraction, report of clinically significant mutation(s) with therapy associations
0330U
Procedures
General
Infectious agent detection by nucleic acid (DNA or RNA), vaginal pathogen panel, identification of 27 organisms, amplified probe technique, vaginal swab
0331U
Procedures
General
Oncology (hematolymphoid neoplasia), optical genome mapping for copy number alterations and gene rearrangements utilizing DNA from blood or bone marrow, report of clinically significant alterations
0332U
Procedures
General
Oncology (pan-tumor), genetic profiling of 8 DNA-regulatory (epigenetic) markers by quantitative polymerase chain reaction (qPCR), whole blood, reported as a high or low probability of responding to immune checkpoint-inhibitor therapy
0333T
Procedures
General
Visual evoked potential, screening of visual acuity, automated
0333U
Procedures
General
Oncology (liver), surveillance for hepatocellular carcinoma (HCC) in high-risk patients, analysis of methylation patterns on circulating cell-free DNA (cfDNA) plus measurement of serum of AFP/AFP-L3 and oncoprotein des-gamma-carboxy-prothrombin (DCP), algorithm reported as normal or abnormal result
0334T
Procedures
General
Sacroiliac joint stabilization for arthrodesis, percutaneous or minimally invasive (indirect visualization), includes obtaining and applying autograft or allograft (structural or morselized), when performed, includes image guidance when performed (eg, CT or fluoroscopic)
0334U
Procedures
General
Oncology (solid organ), targeted genomic sequence analysis, formalin-fixed paraffin-embedded (FFPE) tumor tissue, DNA analysis, 84 or more genes, interrogation for sequence variants, gene copy number amplifications, gene rearrangements, microsatellite instability and tumor mutational burden
0335T
Procedures
General
Extra-osseous subtalar joint implant for talotarsal stabilization
0335U
Procedures
General
Rare diseases (constitutional/heritable disorders), whole genome sequence analysis, including small sequence changes, copy number variants, deletions, duplications, mobile element insertions, uniparental disomy (UPD), inversions, aneuploidy, mitochondrial genome sequence analysis with heteroplasmy and large deletions, short tandem repeat (STR) gene expansions, fetal sample, identification and categorization of genetic variants
0336T
Procedures
General
Laparoscopy, surgical, ablation of uterine fibroid(s), including intraoperative ultrasound guidance and monitoring, radiofrequency
0336U
Procedures
General
Rare diseases (constitutional/heritable disorders), whole genome sequence analysis, including small sequence changes, copy number variants, deletions, duplications, mobile element insertions, uniparental disomy (UPD), inversions, aneuploidy, mitochondrial genome sequence analysis with heteroplasmy and large deletions, short tandem repeat (STR) gene expansions, blood or saliva, identification and categorization of genetic variants, each comparator genome (eg, parent)
0337T
Procedures
General
Endothelial function assessment, using peripheral vascular response to reactive hyperemia, non-invasive (eg, brachial artery ultrasound, peripheral artery tonometry), unilateral or bilateral
0337U
Procedures
General
Oncology (plasma cell disorders and myeloma), circulating plasma cell immunologic selection, identification, morphological characterization, and enumeration of plasma cells based on differential CD138, CD38, CD19, and CD45 protein biomarker expression, peripheral blood
0338T
Procedures
General
Transcatheter renal sympathetic denervation, percutaneous approach including arterial puncture, selective catheter placement(s) renal artery(ies), fluoroscopy, contrast injection(s), intraprocedural roadmapping and radiological supervision and interpretation, including pressure gradient measurements, flush aortogram and diagnostic renal angiography when performed; unilateral
0338U
Procedures
General
Oncology (solid tumor), circulating tumor cell selection, identification, morphological characterization, detection and enumeration based on differential EpCAM, cytokeratins 8, 18, and 19, and CD45 protein biomarkers, and quantification of HER2 protein biomarker-expressing cells, peripheral blood
0339T
Procedures
General
Transcatheter renal sympathetic denervation, percutaneous approach including arterial puncture, selective catheter placement(s) renal artery(ies), fluoroscopy, contrast injection(s), intraprocedural roadmapping and radiological supervision and interpretation, including pressure gradient measurements, flush aortogram and diagnostic renal angiography when performed; bilateral
0339U
Procedures
General
Oncology (prostate), mRNA expression profiling of HOXC6 and DLX1, reverse transcription polymerase chain reaction (RT-PCR), first-void urine following digital rectal examination, algorithm reported as probability of high-grade cancer
0340T
Procedures
General
Ablation, pulmonary tumor(s), including pleura or chest wall when involved by tumor extension, percutaneous, cryoablation, unilateral, includes imaging guidance
0340U
Procedures
General
Oncology (pan-cancer), analysis of minimal residual disease (MRD) from plasma, with assays personalized to each patient based on prior next-generation sequencing of the patient's tumor and germline DNA, reported as absence or presence of MRD, with disease-burden correlation, if appropriate
0341T
Procedures
General
Quantitative pupillometry with interpretation and report, unilateral or bilateral
0341U
Procedures
General
Fetal aneuploidy DNA sequencing comparative analysis, fetal DNA from products of conception, reported as normal (euploidy), monosomy, trisomy, or partial deletion/duplication, mosaicism, and segmental aneuploid
0342T
Procedures
General
Therapeutic apheresis with selective HDL delipidation and plasma reinfusion
0342U
Procedures
General
Oncology (pancreatic cancer), multiplex immunoassay of C5, C4, cystatin C, factor B, osteoprotegerin (OPG), gelsolin, IGFBP3, CA125 and multiplex electrochemiluminescent immunoassay (ECLIA) for CA19-9, serum, diagnostic algorithm reported qualitatively as positive, negative, or borderline
0343T
Procedures
General
Transcatheter mitral valve repair percutaneous approach including transseptal puncture when performed; initial prosthesis
0343U
Procedures
General
Oncology (prostate), exosome-based analysis of 442 small noncoding RNAs (sncRNAs) by quantitative reverse transcription polymerase chain reaction (RT-qPCR), urine, reported as molecular evidence of no-, low-, intermediate- or high-risk of prostate cancer
0344T
Procedures
General
Transcatheter mitral valve repair percutaneous approach including transseptal puncture when performed; additional prosthesis (es) during same session (List separately in addition to code for primary procedure)
0344U
Procedures
General
Hepatology (nonalcoholic fatty liver disease [NAFLD]), semiquantitative evaluation of 28 lipid markers by liquid chromatography with tandem mass spectrometry (LC-MS/MS), serum, reported as at-risk for nonalcoholic steatohepatitis (NASH) or not NASH
0345T
Procedures
General
Transcatheter mitral valve repair percutaneous approach via the coronary sinus
0345U
Procedures
General
Psychiatry (eg, depression, anxiety, attention deficit hyperactivity disorder [ADHD]), genomic analysis panel, variant analysis of 15 genes, including deletion/duplication analysis of CYP2D6
0346T
Procedures
General
Ultrasound, elastography (List separately in addition to code for primary procedure)
0346U
Procedures
General
Beta amyloid, AB40 and AB42 by liquid chromatography with tandem mass spectrometry (LC-MS/MS), ratio, plasma
0347T
Procedures
General
Placement of interstitial device(s) in bone for radiostereometric analysis (RSA)
0347U
Procedures
General
Drug metabolism or processing (multiple conditions), whole blood or buccal specimen, DNA analysis, 16 gene report, with variant analysis and reported phenotypes
0348T
Procedures
General
Radiologic examination, radiostereometric analysis (RSA); spine, (includes cervical, thoracic and lumbosacral, when performed)
0348U
Procedures
General
Drug metabolism or processing (multiple conditions), whole blood or buccal specimen, DNA analysis, 25 gene report, with variant analysis and reported phenotypes
0349T
Procedures
General
Radiologic examination, radiostereometric analysis (RSA); upper extremity(ies), (includes shoulder, elbow, and wrist, when performed)
0349U
Procedures
General
Drug metabolism or processing (multiple conditions), whole blood or buccal specimen, DNA analysis, 27 gene report, with variant analysis, including reported phenotypes and impacted gene-drug interactions
0350T
Procedures
General
Radiologic examination, radiostereometric analysis (RSA); lower extremity(ies), (includes hip, proximal femur, knee, and ankle, when performed)
0350U
Procedures
General
Drug metabolism or processing (multiple conditions), whole blood or buccal specimen, DNA analysis, 27 gene report, with variant analysis and reported phenotypes
0351T
Procedures
General
Optical coherence tomography of breast or axillary lymph node, excised tissue, each specimen; real-time intraoperative
0351U
Procedures
General
Infectious disease (bacterial or viral), biochemical assays, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein, serum, algorithm reported as likelihood of bacterial infection
0352T
Procedures
General
Optical coherence tomography of breast or axillary lymph node, excised tissue, each specimen; interpretation and report, real-time or referred
0352U
Procedures
General
Infectious disease (bacterial vaginosis and vaginitis), multiplex amplified probe technique, for detection of bacterial vaginosis-associated bacteria (BVAB-2, Atopobium vaginae, and Megasphera type 1), algorithm reported as detected or not detected and separate detection of Candida species (C. albicans, C. tropicalis, C. parapsilosis, C. dubliniensis), Candida glabrata/Candida krusei, and trichomonas vaginalis, vaginal-fluid specimen, each result reported as detected or not detected
0353T
Procedures
General
Optical coherence tomography of breast, surgical cavity; real-time intraoperative
0353U
Procedures
General
Infectious agent detection by nucleic acid (DNA), Chlamydia trachomatis and Neisseria gonorrhoeae, multiplex amplified probe technique, urine, vaginal, pharyngeal, or rectal, each pathogen reported as detected or not detected
Showing page 16 of 253 (Total: 12623 codes)

The Ultimate Guide to CPT Coding: Navigating the Outpatient Revenue Cycle

The Current Procedural Terminology (CPT®) code set, maintained and copyrighted by the American Medical Association (AMA), is the universal language of medicine in the United States outpatient setting. It is utilized to report medical, surgical, and diagnostic procedures and services to entities such as physicians, health insurance companies, and accreditation organizations. For the Certified Professional Coder (CPC), mastering the CPT manual is the cornerstone of professional fee (ProFee) and ambulatory surgery center (ASC) coding.

Unlike ICD-10-CM which describes the "why" (the diagnosis), CPT describes the "what" (the service or procedure performed). Translating a complex operative report or an Evaluation and Management (E/M) encounter into a 5-digit CPT code requires a profound understanding of medical terminology, anatomy, and the labyrinth of AMA guidelines. A single coding error can result in massive revenue leakage, compliance violations, or severe audit penalties.

CPC Coder's Note: The Importance of the Parenthetical Notes

Never code directly from the alphabetic index. The true power of the CPC lies in reading the parenthetical notes situated directly beneath the CPT codes in the tabular section. These notes dictate bundling rules, direct the coder to the correct alternative codes, and provide strict instructions on when a modifier is necessary. Ignoring a parenthetical note is a guaranteed path to a claim denial.

The Three Categories of CPT Codes

The CPT code set is divided into three distinct categories, each serving a unique purpose in the healthcare ecosystem.

Category I Codes

These are the core, 5-digit numeric codes that make up the vast majority of the CPT manual. They represent procedures and services that are widely performed by many healthcare professionals in clinical practice and are approved by the FDA. Category I is divided into six main sections:

  • Evaluation and Management (99202–99499): Cognitive services, office visits, hospital observations, and consultations.
  • Anesthesiology (00100–01999): Anesthesia services, categorized by anatomical site.
  • Surgery (10021–69990): The largest section, covering all surgical procedures organized by body system (Integumentary, Musculoskeletal, Respiratory, Cardiovascular, etc.).
  • Radiology (70010–79999): Diagnostic imaging, ultrasound, radiation oncology, and nuclear medicine.
  • Pathology and Laboratory (80047–89398): Organ or disease-oriented panels, drug testing, hematology, and surgical pathology.
  • Medicine (90281–99607): Immunizations, psychiatry, physical therapy, ophthalmology, and cardiac catheterizations.

Category II Codes

These are supplemental tracking codes used for performance measurement and quality tracking. They are alphanumeric (e.g., 3008F - Body Mass Index documented). While Category II codes are generally optional and do not carry a relative value unit (RVU) for direct reimbursement, they are highly critical in value-based purchasing agreements, MIPS (Merit-based Incentive Payment System), and MACRA reporting to secure quality bonuses.

Category III Codes

These are temporary alphanumeric codes (ending in "T") utilized for emerging technologies, services, and procedures (e.g., 0101T - Extracorporeal shock wave involving musculoskeletal system). They allow researchers and the AMA to track the utilization of new technologies before they are granted Category I status. If a Category III code exists for a specific procedure, it must be utilized instead of an "unlisted" Category I code.

Mastering Evaluation and Management (E/M)

Historically, E/M coding was the most heavily audited and contentious area of medical coding, governed by the archaic 1995 and 1997 CMS Documentation Guidelines. These old guidelines required physicians to "bullet count" physical exam elements and history of present illness (HPI) components, leading to massive documentation bloat ("note bloat") in Electronic Health Records.

The AMA and CMS radically overhauled E/M coding (effective 2021 for outpatient/office, and 2023 for inpatient/facility). Today, the selection of an E/M level is based strictly on one of two criteria:

  • Medical Decision Making (MDM): The cognitive effort required to treat the patient. MDM is determined by evaluating three elements: the number and complexity of problems addressed, the amount and/or complexity of data reviewed/analyzed, and the risk of complications and/or morbidity or mortality of patient management.
  • Total Time: If time is the determining factor, it now includes both face-to-face and non-face-to-face time spent by the physician on the day of the encounter (e.g., reviewing records before the patient arrives, charting after the patient leaves).

The Surgery Section: Global Periods and Unbundling

Surgical coding is governed by the concept of the Global Surgical Package. When a payer reimburses a surgical CPT code, the payment covers not just the intraoperative procedure, but also the local/topical anesthesia, normal uncomplicated follow-up care, and typical preoperative encounters.

  • 0-Day Global: Minor procedures (e.g., endoscopies). No post-operative days are included.
  • 10-Day Global: Minor procedures with a 10-day post-operative period included (e.g., simple laceration repair).
  • 90-Day Global: Major surgeries (e.g., joint replacements, open heart surgery). Includes 1 day pre-operative and 90 days post-operative care.

One of the primary directives of a CPC is to prevent Unbundling. Unbundling occurs when a coder reports multiple CPT codes for components that are inherently part of a single, major procedure. To prevent this, coders rely on the National Correct Coding Initiative (NCCI) Edits. These edits dictate which codes cannot be billed together. For example, you cannot bill an exploratory laparotomy alongside an open appendectomy, as the surgical approach is bundled into the definitive procedure.

The Power of CPT Modifiers

Modifiers are two-digit codes appended to a CPT code to indicate that a service or procedure has been altered by some specific circumstance but not changed in its definition. Applying the correct modifier is the ultimate test of a coder's compliance knowledge. Incorrect modifier usage is the leading cause of Office of Inspector General (OIG) audits.

Critical Modifiers for the CPC:

  • Modifier 25: Significant, Separately Identifiable Evaluation and Management Service by the Same Physician on the Same Day of the Procedure or Other Service. (e.g., A patient comes in for a scheduled knee injection, but also complains of a new, acute asthma attack. The asthma evaluation is billed with a -25 modifier). This is the most heavily audited modifier in existence.
  • Modifier 59 / X-Modifiers (XE, XP, XS, XU): Distinct Procedural Service. Used to bypass an NCCI edit when a procedure is performed on a separate anatomical site, through a separate incision, or during a separate session on the same day.
  • Modifier 24: Unrelated Evaluation and Management Service by the Same Physician During a Postoperative Period. Used when a surgeon sees a patient for a completely new issue during the 90-day global period of a previous surgery.
  • Modifier 57: Decision for Surgery. Appended to an E/M code when the visit results in the initial decision to perform a major surgical procedure (90-day global) on that day or the next.
  • Modifier 52: Reduced Services. Used when a procedure is partially reduced or eliminated at the physician's discretion.

Relative Value Units (RVUs) and the Physician Fee Schedule

CPT codes are intrinsically tied to physician compensation via the Medicare Physician Fee Schedule (MPFS). Every Category I CPT code is assigned a Relative Value Unit (RVU), which quantifies the resources required to perform the service. The total RVU is calculated by adding three components:

  • Work RVU (wRVU): The physician's time, mental effort, technical skill, and psychological stress. (This is how most physicians calculate their productivity bonuses).
  • Practice Expense RVU (peRVU): The overhead costs of the practice (staff salaries, rent, medical supplies). This varies based on whether the procedure is performed in a facility (hospital) or non-facility (private office).
  • Malpractice RVU (mpRVU): The cost of professional liability insurance.

The Total RVU is then multiplied by a geographic practice cost index (GPCI) and the annual Medicare Conversion Factor to calculate the exact dollar amount of reimbursement.

The Role of the CPC in the Revenue Cycle

The Certified Professional Coder is the final line of defense in the revenue cycle. A physician may perform an incredible, life-saving surgery, but if the CPC fails to correctly sequence the CPT codes, apply the correct NCCI bypass modifiers, or link the procedures to the highest-specificity ICD-10-CM diagnosis codes to prove Medical Necessity, the claim will be denied.

Beyond abstracting codes from documentation, modern CPCs act as clinical educators. They regularly audit provider documentation to ensure compliance with AMA guidelines, train physicians on the nuances of the 2021/2023 E/M updates, and query providers when an operative report lacks the critical details required to assign a complex surgical code.

Conclusion

The CPT code set is a dynamic, continuously evolving language that adapts to the cutting edge of medical science. New technologies, novel surgical techniques, and telemedicine expansions require the AMA to update the manual annually every January 1st.

For the professional medical coder, fluency in CPT is the key to unlocking the financial viability of a healthcare organization. It demands rigorous analytical skills, an unwavering commitment to ethical compliance, and a deep respect for the clinical realities of patient care. Whether you are coding a simple office visit or a multi-stage cardiothoracic surgery, your mastery of CPT ensures that the physician's work is accurately recognized, fully reimbursed, and protected from retrospective audits.

Free CPT Code Lookup & Search Tool

Welcome to the most comprehensive and lightning-fast CPT code lookup tool available online. Whether you are a dedicated health information management (HIM) professional, a certified medical coder, a specialized biller, or a clinical data analyst, our advanced search engine allows you to instantly search CPT codes and find highly accurate code descriptions in mere milliseconds. Navigating the complex world of healthcare terminology requires precision, and our platform is built to deliver exactly that.

Looking up medical codes can often be a frustrating and time-consuming experience, especially when relying on slow, clunky platforms or physical manuals that quickly become outdated. Our dedicated CPT search directory elegantly bridges that gap. By utilizing our highly optimized, state-of-the-art database, you can effortlessly find CPT code descriptions by simply typing a keyword, a specific diagnosis or procedure, an anatomical site, or the exact alphanumeric code itself. The results are rendered in real-time as you type, allowing you to completely bypass cumbersome PDF manuals and heavy physical coding books, streamlining your daily workflow.

How to Use Our CPT Search Engine for Maximum Efficiency

To perform an accurate CPT lookup, navigate to the intuitive search bar located at the top of this page. If you have a specific clinical term or abstract concept in mind, simply type the term into the search field. Our intelligent, NLP-driven algorithm will instantly scan the entire official database to populate a comprehensive list of matching CPT codes and descriptions. Conversely, if you already possess the specific code and simply need to verify its validity or read the full tabular guidelines, you can type the identifier directly into the bar to instantly verify its official long-form description.

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Why Fast, Accurate Medical Code Lookup Matters in Healthcare

In the incredibly fast-paced environment of medical auditing, clinical documentation improvement (CDI), and revenue cycle management (RCM), time literally equates to money. Slow, laggy search platforms cause unnecessary friction and contribute to coder burnout. That is exactly why our free CPT lookup tool is aggressively engineered to return complex search results in under 120 milliseconds. We have heavily optimized our backend server architecture so that the moment you need to look up a CPT code, the data is delivered instantaneously. This relentless focus on performance makes our platform the premier, go-to destination for anyone in the healthcare industry asking, "How do I find a CPT code description quickly and reliably?"

We highly recommend that you bookmark this page as your daily, primary resource for all your CPT code search needs. We are deeply committed to maintaining this robust, frequently updated database as a permanent, free public utility for the global healthcare data community. Start typing your query into the search bar above to experience the absolute fastest, most reliable medical code lookup available on the internet today. Say goodbye to endless scrolling, frustrating page loads, and outdated indexes. Let our powerful, instantaneous search engine do the heavy lifting for your clinical documentation and coding operations. Whether you are aggressively searching by an exact code, a partial clinical description, or a broad medical category, our advanced tool delivers the exact CPT code information you need to ensure total compliance and financial accuracy.